At CHEMAS, we want to make it easy for you to understand our product and contact us if you have any further questions.
We have listed here the most commonly asked questions and we will answer any inquiries as soon as possible by e-mail.
What is CM-7919?
CM-7919 is a anticancer drug with very few side effects
whose active pharmaceutical ingredient is As4O6
STRUCTURE
As4O6 (Tetraarsenic hexaoxide, molecular weight 395.6)
* Anti-angiogenesis
* Induction of Apoptosis
* Anti-NF-KB activity which is generally increased in advanced cancer
brain cancer, renal cancer, bladder cancer, and maxillary sinus cancer and more
* Effective in treating blood cancers such as multiple myeloma
* Highly effective in reducing cancer pain
* Almost no side effects or drug intolerance
* Increase in efficacy when used in combination with radiotherapy and other cancer drugs
* Sufficient safety margin
* Possible to develop into an injectable version
* Highly effective in relieving cancer pain
CM-7919's active pharmaceutical ingredient is arsenic, which is known to be toxic. Should I be concerned about the potential toxic issues?
In preclinical trials including ADME (absorption, distribution, metabolism, and excretion) evaluation, it was proved that there is almost no toxicity in As4O6, especially in appropriate dosage, and found out that As4O6 is completely removed from the body after 2-3 days. After gaining approval for Phase 1 clinical trials from MFDS(Korean Ministry of Food and Drug Safety), Phase 1 clinical trial was conducted at Asan Medical Center on 15 patients with terminal cancer whose previous surgical operations, chemotherapy and radiotherapy treatments had not successfully inhibited tumor progression.
What is the mechanism of CM-7919?
- Pyroptosis
- Anti-angiogenesis
- Induction of apoptosis
- Anti-NF-KB activity which is generally increased in advanced cancer
Are arsenic-based drugs used to treat cancer?
Yes. Arsenic trioxide(As2O3) and As4S4 have been used for cancer treatment. As2O3 is now used as a standard treatment for refractory acute promyelocytic leukemia (APL) and As4S4 is used to treat Chronic Myelogenous Leukemia (CML).
Are there any published articles on Tetraarsenic hexaoxide?
Yes. Researches on arsenic compounds are being carried out throughout the world and there are hundreds of articles addressing the anticancer effect of arsenic. In particular, there are more than 30 articles suggesting As4O6-containing CM-7919 developed by CHEMAS has notable anticancer effects.
What was the result of Phase 1 clinical trials?
In Phase 1 clinical trials conducted for 4 weeks according to WHO criteria, none of the adverse drug reactions was observed. The trial was conducted on 15 patients with terminal cancer whose previous anticancer treatments had been unsuccessful (including surgical operations, chemotherapy and radiotherapy). During this trial, 10 out of 15 patients experienced reduction in tumor size, cancer growth had stopped, and patients’ quality of life significantly improved.
Contact us by email and we will get back to you within 2-3 business days. If you need a quicker response, please call us.
info@chemas.co.kr
Tel +82.2.3472.7503
Fax +82.2.3472.7507
Samha Bldg 3F
502, Bongeunsa-ro
Gangnam-gu, Seoul, KOREA