Mechanism

Mechanism
1. Pyroptosis

We were able to observe As4O6 inducing pyroptosis in cancer cells. Cell membrane was ruptured by GSDME protein activation, followed by strong inflammatory reaction, eventually leading to cell death.

2. Anti-angiogenesis

CM-7919 (As4O6) inhibits the growth of cancer by blocking the angiogenic switch which leads to tumor expression of pro-angiogenic factors and increased tumor vascularization.

< Process of Angiogenesis >

mechanism_01
  1. Generation of angiogenesis factor
    (As4O6 blocks chemical signals from tumor cells)
  2. Discharge
  3. Binding to receptor on endothelial cells
  4. Proliferation of endothelial cells
mechanism_02
  1. Control of extracelluar materials and migration of endothelial cells
mechanism_03
  1. Vascularization
  2. Formation of vascular circle
  3. Stabilization of vascular system
3. Apoptosis

As4O6 induces apoptosis and the expression of apoptosis-related proteins by significantly suppressing the proliferating cell nuclear antigen.

4. Suppression of NF-KB activity

As4O6 suppress downstream NF-KB-regulated proteins involved in cancer anti-apoptosis, proliferation, invasion and metastasis and NF-KB-mediated cellular responses.

Search